Using the image above as reference, this is a simple way to memorise the process.
- Enzyme helicase unwind the parental double helix.
- The single strand binding proteins stablise the parental DNA
- The leading strand is synthesised continously in the 5' to 3' direction by DNA polymerase III
- The lagging strand is synthesised discontinuously. Primase synthesises a short RNA primer to form Okazaki fragment
- RNA primer is replaced by DNA polymerase I, then DNA ligase joins the Okazaki fragment to the growing strand.
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